Endocrine Abstracts

Background: Nicotinamide phosphoribosyltransferase (NAMPT)/PBEF/visfatin is a widely expressed cytokine with various effects on glucose and lipid metabolism, cell survival, and inflammation. Despite a favorable body composition profile, acromegalic patients present insulin resistance, increased cardiovascular risk, and higher incidence of secondary tumors.Aim: Based on its relation to glucose and lipid metabolism and inflammation we hypothesized that NAM...

Introduction: E-cadherins are found in epithelial tissue. Reduced expression in somatotroph pituitary adenomas has been demonstrated to correlate with dedifferentiated phenotype; reduced tumour size, increased invasiveness, and reduced somatostatin analog response. Recently, correlations between corticotroph tumour dedifferentiation and both E-cadherin immunostaining and reduced E-cadherin gene (CDH1) mRNA was demonstrated.Glucocorticoids induces ...